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Fluvoxamine—Coadministration of fluvoxamine approximately doubled the alprazolam maximum plasma concentration of alprazolam, decreased clearance by 49%, increased half-life by 71%, and decreased measured psychomotor performance .
Reference alprazolam tablets buy xanax dosage too high xanax 0.5 mg cut in half xanax .25 mg drug test 1mg ID: 4029640 Cimetidine—Coadministration of cimetidine increased the maximum plasma concentration of alprazolam by 86%, decreased clearance by 42%, and increased half-life by 16% .
Other drugs possibly affecting alprazolam metabolism Other drugs possibly affecting alprazolam alprazolam metabolism by inhibition of CYP3A are discussed in the PRECAUTIONS section (see PRECAUTIONS–Drug Interactions) .
As with other psychotropic medications, the usual precautions with respect to administration of the drug and size of the prescription are indicated for severely depressed patients or those in whom there is reason to expect concealed alprazolam suicidal ideation or plans .
Panic disorder has been associated with primary and secondary major depressive disorders and increased alprazolam reports of suicide among untreated patients .
Episodes of hypomania and mania have been reported in association with the use of XANAX in patients alprazolam round blue pill xanax dosage per weight benzo withdrawal weight gain what is generic with depression .
Uricosuric Effect alprazolam Alprazolam has a weak uricosuric effect .
Although other medications with weak uricosuric effect have been reported to cause acute renal failure, there have been no reported instances of acute renal failure attributable alprazolam to therapy with XANAX .
Use in Patients with Concomitant Illness It is recommended that the dosage be limited to the smallest effective dose to preclude the development of ataxia or oversedation alprazolam which may be a particular problem in elderly or debilitated patients .
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